While AI chips steal the headlines, sector rotation has quietly favored weightloss pharma, domestic refiners, megabanks and EV autonomy as investors seek earnings visibility in a higherforlonger rate backdrop. Below are five S&P stalwarts whose 2025 catalysts and chart structures merit attention into midyear.

Crosscurrents driving rotation

• Inflation plateau. Sticky services CPI is delaying deep rate cuts, boosting bank netinterest margins but capping P/E on longduration tech.
• Energy policy tugofwar. Tariff angst on Chinese refined products and Iranrelated supply shocks keep a bid under crude, supporting integrated oils .
• Healthcare repricing. GLP1 obesity drugs create a new $100 billion TAM through 2030, masking electionyear pricecontrol chatter.

1. Eli Lilly (LLY) – Owning the obesity megatrend

Fundamental edge. Street models call for 18 % topline growth to $52.8 billion in 2025 with EPS approaching $19.11, implying a price target north of $1 140 at 60 × forward earnings. Oral GLP1 candidate Orforglipron just hit all Phase 3 endpoints, opening a pillbased market segment.

Catalysts.

• SURPASSCVOT cardiovascularoutcome readout (Q3) could widen insurance coverage for Zepbound .
• Supply expansion from the new Concord, NC plant.

Technical map. ChartMill highlights a support shelf $714–726 and layered resistance zones at $853, $878, $898 and $921–948. SwingTradeBot flags nearer supports $786 → $766 → $755 with resistance $818 → $829 → $850; a 50DMA crossup just fired.

2. Tesla (TSLA) – From EV maker to mobility platform

Fundamental edge. Goldman Sachs argues Tesla’s vertically integrated AI stack (custom silicon, camera vision) gives it a leg up in the robotaxi race. Management reaffirmed a June 2025 paid robotaxi launch in Austin with dedicated Cybercab production in 2026.

Catalysts.

• NHTSA approval for FSD v12.
• Licensing deals with other OEMs for Tesla’s charger and autonomy stack.

Technical map. After a 14 % plunge on 6 June, price broke below the 50 and 200DMA; Investopedia identifies key supports at $265 → $215 → $170 and major resistance near $365. YouTube technicians peg intraday pivots around $282 (R1) and $258 (S1) . Tactical traders can look for meanreversion longs at oversold RSI <30.

3. Exxon Mobil (XOM) – Cashreturn machine in an underowned sector

Fundamental edge. Despite Brent stabilizing in the $90s, Exxon reaffirmed its capitalreturn framework, supporting a 3.75 % dividend yield and continued buybacks. Longcycle Guyana expansion offers low breakeven barrels.

Catalysts.

• Potential spinoff of lowcarbon solutions unit could unlock sumofparts value.
• Seasonal hurricane risk can tighten Gulf Coast product markets.

Technical map. Barchart pivot matrix shows clustered support $106 → $104 with resistance $111; the weekly chart is carving a higherlows structure. A breakout above $111 opens room toward the 2022 high at $119.

4. JPMorgan Chase (JPM) – Beneficiary of higherforlonger

Fundamental edge. Shares trade near $266 after touching $280 YTD, reflecting resilience in trading and card spend. Every 25 bp fedfunds spread adds roughly $3 billion to NII. Fortress balance sheet enables steady buybacks even under GSIB surcharges.

Catalysts.

• June CCAR results could greenlight a dividend hike.
• Acceleration in capitalmarkets fee pool if IPOs thaw.

Technical map. Barchart pivots show first support $261, then $255 with resistance $273 barchart.com. A weekly close above $273 would complete a sixmonth cupandhandle, projecting $300 intermediateterm.

5. Meta Platforms (META) – The ad engine is back, now with AI assist

Fundamental edge. Advantage+ shopping ads plus Reels monetization have reignited doubledigit topline growth, while Llama  3 positions Meta as an opensource AI power.

Catalysts.

• Quest 4 mixedreality headset unveil at Connect ’25.
• Potential spinout/IPO of WhatsApp Payments in India.

Technical map. Economies.com sets $662.70 as musthold support and targets a pivotal resistance at $740.90. Barchart data corroborate intraday pivot resistance at $744 and support at $680. Look for breakouts on expanding OBV to confirm institutional participation.

Tactical playbook

Theme	Entry bias	Preferred vehicle	Risk trigger	Target through Juneend
GLP1 demand	Buy dips near $765 LLY	Stock or Jul $800 calls	Close < $740	Retest $850
Robotaxi hype	Breakout over $282 TSLA	Aug $300 calls	Close < $258	Gapfill $310
Energy reflation	Trendfollow above $111 XOM	Covered calls	Close < $104	$119 swing
NII expansion	Buy pullback to $255 JPM	Stock & div capture	50DMA breach	$285
Socialad rebound	Momentum above $741 META	Bull call spread	Close < $680	$800

Position sizing tip: Allocate no more than 5 % capital per idea and hedge beta with short QQQ or ratesensitive utilities if Fed path surprises.

Final thoughts

These ten names—five AI infrastructure titans and five sectorrotation standouts—capture the dominant narratives steering the S&P 500 into mid2025: unprecedented datacenter investment, breakthrough obesity therapeutics, autonomous mobility, energy security and higherforlonger interest rates. By anchoring entries to clearly defined support/resistance zones and staying alert to macro catalysts, traders can exploit both momentum and meanreversion setups while the market digests an unusually rich pipeline of innovation and policy crosscurrents.